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Flu Season Frequently Asked Questions - High Dose Seasonal Influenza Vaccine
What is Fluzone High-Dose influenza vaccine?
Fluzone High-Dose is an influenza vaccine manufactured by Sanofi Pasteur Inc., designed specifically for people 65 years and older.
What is the difference between regular Influenza vaccine and Fluzone High-Dose?
High-Dose vaccine contains four times the amount of antigen (the part of the vaccine that prompts the body to make antibody) contained in regular flu shots. The additional antigen is intended to create a stronger immune response (more antibody) in the person getting the vaccine.
Why is a higher dose vaccine available for adults 65 and older?
Human immune defenses become weaker with age, which places older people at greater risk of severe illness from influenza. Also, ageing decreases the body's ability to have a good immune response after getting influenza vaccine. A higher dose of antigen in the vaccine is supposed to give older people a better immune response, and therefore, better protection against the flu.
Does the higher dose vaccine produce a better immune response in adults 65 and older?
Data from clinical trials comparing regular Fluzone to Fluzone High-Dose among persons aged 65 years or older indicate that a stronger immune response (i.e., higher antibody levels) occurs after vaccination with Fluzone High-Dose. An ongoing study designed to determine the effectiveness of Fluzone High-Dose in preventing illness from influenza compared to routine Fluzone suggests that High Dose vaccine is more effective in reducing flu illness than routine vaccine in those >=65years.
Is Fluzone High-Dose safe?
The safety profile of Fluzone High-Dose vaccine is similar to that of regular flu vaccines, although some adverse events (which are also reported after regular flu vaccines) were reported more frequently after vaccination with Fluzone High-Dose. The most common adverse events experienced during clinical studies were mild and temporary, and included pain, redness and swelling at the injection site, headache, muscle aches, fever and malaise. Most people had minimal or no adverse events after receiving the Fluzone High-Dose vaccine.
Who can get this vaccine?
Fluzone High-Dose is approved for use in people 65 years of age and older. As with all flu vaccines, Fluzone High-Dose is not recommended for people who have had a severe reaction to the flu vaccine in the past.
Does CDC recommend one vaccine above another for people 65 and older?
CDC and the Advisory Committee on Immunization Practices (ACIP) recommends flu vaccination as the first and most important step in protecting against the flu; however, neither CDC or ACIP has expressed a preference for one vaccine over another at this time.
Source: The Centers for Disease Control & Prevention (CDC)